Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice
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چکیده
منابع مشابه
Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, its etiology and underlying mechanisms remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Initially, the female Mito-Ob mice were equally fertile to their wild-type litte...
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Hyperandrogenic anovulation is characterized by polycystic appearance of the ovaries, elevated free serum testosterone with decreased concentrations of serum sex hormone binding globulin, an increased ratio of luteinizing hormone to follicle stimulating hormone and varying degrees of insulin resistance. We hypothesize that this is the result of variably increased 'ovarian androgenic insulin res...
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BACKGROUND Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility and menstrual cycle abnormalities, but the factors responsible for failure to select a dominant follicle remain unclear. METHOD Source is authors' own studies and search of the relevant literature. RESULTS Arrest of antral follicle growth is associated with an abnormal endocrine environment involvi...
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Background: Earlier studies on the effect of constant electro-acupuncture (EA) treatments in rats with drug-induced polycystic ovary syndrome (PCOS), has been shown to revise the hormones and neurotransmitter levels. Aim: The present study was conducted with the aim to test the hypothesis that repeated EA treatment modulates Epinephrine (EPI) and Norepinephrine (NE) level of PCOS and anovulatio...
متن کاملObesity and polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of fertile age. Obesity is encountered in 30-70% of PCOS-affected women, and its presence significantly modifies both clinical and laboratory expression of the syndrome. Obesity increases the risk of co-morbidities associated with PCOS, such as impaired glucose tolerance and type 2 diabetes mellitus, hyperlipid...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2017
ISSN: 2046-6390
DOI: 10.1242/bio.023416